Organ Pipe Cactus National Monument is a U.S. national monument and UNESCO biosphere reserve located in extreme southern Arizona that shares a border with the Mexican state of Sonora. The park is the only place in the United States where the senita and organ pipe cactus grow wild. Along with this species, many other types of cacti and other desert flora native to the Yuma Desert section of the Sonoran Desert region grow in the park. Organ Pipe Cactus National Monument is 517 sq mi in size.