Our Lady of Guadalupe Catholic Church (Iglesia Nuestra Señora de Guadalupe) is a Roman Catholic church located in the Second Ward in the East End, Houston, Texas. It is a part of the Roman Catholic Archdiocese of Galveston-Houston. The church, first constructed in 1911, was the first Mexican-American church in Houston. It was the first religious institution in the City of Houston to offer religious services in the Spanish language.