Empire Hotel is a heritage-listed hotel at 339 Brunswick Street, Fortitude Valley, City of Brisbane, Queensland, Australia. It was designed by Richard Gailey and built in 1888 by Smith and Ball. It was renovated in 1925 to a design by Richard Gailey, Junior. It was further renovated in 1937 to incorporate apartments designed by Hall and Phillips. It was added to the Queensland Heritage Register on 21 October 1992.