The Mississippi Lofts and Adler Theatre is an apartment building and theater complex located in downtown Davenport, Iowa, United States. It is individually listed on the National Register of Historic Places by its original name, the Hotel Mississippi and RKO Orpheum Theater. The Hotel Mississippi was listed on the Davenport Register of Historic Properties in 2005. In 2020 the complex was included as a contributing property in the Davenport Downtown Commercial Historic District.