The San Luis Port of Entry has been a busy US port of entry since the early 1900s. It connects San Luis, Arizona, to San Luis Río Colorado, Sonora. It connects to U.S. Route 95 on the north and Mexican Federal Highway 2 as well as Sonora State Highway 40 on the south. In 2010, all commercial truck traffic was diverted to the new San Luis II Port of Entry 5 miles to the east. In 2012, two additional inspection lanes were added to the port facility..