Hoogezand-Sappemeer is an unstaffed railway station in Hoogezand-Sappemeer in the Netherlands. It is located on the Harlingen–Nieuweschans railway between Martenshoek and Sappemeer Oost in the province of Groningen. Train services started in 1868 and the current station building was completed in 1989. There are currently three train services, all operated by Arriva.