Groß Gerau station is located approximately 500 metres north of the centre of the town of Groß-Gerau in the German state of Hesse on the Rhine-Main Railway, running from Wiesbaden and Mainz to Darmstadt and Aschaffenburg. A curve branches off near the station connecting to the nearby Groß-Gerau-Dornberg station on the Mannheim–Frankfurt railway. The station is classified by Deutsche Bahn as a category 5 station.