City of Hope is a private, not-for-profit clinical research center, hospital and graduate medical school located in Duarte, California, United States. The center's main campus resides on 110-acre of land adjacent to the boundaries of Duarte and Irwindale, with a network of clinical practice locations throughout Southern California, satellite offices in Monrovia and Irwindale, and regional fundraising offices throughout the United States. City of Hope is best known as a cancer treatment center.