The Río Plátano Biosphere Reserve is 5,250 km² of preserved land in the La Mosquitia region on the Caribbean coast of Honduras. Most of the land runs along the Río Plátano. The reserve has a number of endangered species and some of Honduras largest sections of forest. It has been a World Heritage site and biosphere reserve since 1982. In 2011, UNESCO placed the reserve on the List of World Heritage in Danger.