The Teatro Caio Melisso is an opera house located in Spoleto, Italy and it serves as the main venue for opera performances during the annual summer Festival dei Due Mondi. The theatre has undergone several transformations and name changes since the late 17th century. The Teatro di Piazza del Duomo, also known as the Teatro della Rosa, built around 1667 was modernized in 1749 and re-opened in 1749 as the Nuovo Teatro di Spoleto.