22nd Street is a Caltrain commuter rail station on 22nd Street beneath the I-280 freeway in San Francisco, California. It is the only below-grade station in the Caltrain system. The only way for passengers to reach the platforms is by stairway, so the station is not accessible to persons with disabilities. Like all Caltrain stations except San Francisco 4th & King and San Jose Diridon, the station is unstaffed; passengers buy tickets from machines.