Khon Kaen Wittayayon School is a public school located in downtown Khon Kaen Province, Thailand. It admits secondary students (mathayom 1–6, equivalent to grades 7–12). Founded in 1897 as a boys' school for Khon Kaen Province, it then became the first coeducational school in Khon Kaen. The school's former names were "Khon Kaen (boys') School" and "That Wittayakhan Temple School". The first school principal was Mr. Tub Chimma.