The National Mississippi River Museum & Aquarium is a museum located in Dubuque, Iowa, USA. The museum is a property of the Dubuque County Historical Society, with two centers on the riverfront campus: the Mississippi River Center and the National River Center. The museum is an affiliate of the Smithsonian Institution, and is accredited by the American Alliance of Museums (AAM) and the Association of Zoos and Aquariums (AZA).