Museo de Arte de Ponce is an art museum located on Avenida Las Américas in Ponce, Puerto Rico. It houses a collection of European art, as well as works by Puerto Rican artists. The museum contains one of the most important Pre-Raphaelite collections in the Western Hemisphere, holding some 4,500 pieces of art distributed among fourteen galleries. Museo de Arte de Ponce is the finest art museum in Puerto Rico.