Parkesburg is an Amtrak train station located between Lancaster and Philadelphia at West First Avenue and South Culvert Street in Parkesburg, Pennsylvania. It is served by most Amtrak Keystone Service trains. A station building exists at the stop, but is not currently used as a ticket office. The distance between Parkesburg and the next westbound station is the longest distance between stations (23 miles) anywhere within the Pennsylvania section of the Keystone Service.