The Port St. Lucie Botanical Gardens is a 21-acre subtropical botanical garden located at 2410 SE Westmoreland Blvd, Port St. Lucie, Florida, United States. The garden opened in March 2010 and is operated by The Friends of the Port St. Lucie Botanical Gardens, a non-profit, 501 3 educational foundation. The construction of the garden began on March 4, 2009 and the grand opening was on March 6, 2010.