Ascoli Piceno railway station serves the town and comune of Ascoli Piceno, in the region of Marche, central Italy. Opened in 1886, it is the southwestern terminus of the San Benedetto del Tronto–Ascoli Piceno railway, a branch of the Adriatic railway. The station is managed by Rete Ferroviaria Italiana (RFI). The commercial area of the passenger building is managed by Centostazioni. Train services are operated by Trenitalia.