Centre Market Square Historic District is a historic district in Wheeling, West Virginia, listed on the National Register of Historic Places. The district includes 181 contributing buildings in a variety of popular architectural styles dating from as early as about 1850. The district encompasses the area of Wheeling focused on the separately listed Center Wheeling Market. Notable buildings include the Second Presbyterian Church (1850), St. Alphonsus Church and School (1875, 1887), Mary A.