Rancho Guajome Adobe is a historic 19th-century hacienda in Rancho Guajome Adobe County Park, on North Santa Fe Avenue in Vista in San Diego County, California. Built in 1852–53, it is a well-preserved but late example of Spanish-Mexican colonial architecture, and was designated a National Historic Landmark in 1970. It is also a California Historical Landmark and on the National Register of Historic Places.