The Trans-Allegheny Lunatic Asylum, subsequently the Weston State Hospital, was a Kirkbride psychiatric hospital that operated from 1864 until 1994 by the government of the U.S. state of West Virginia, in the city of Weston. Built by architect Richard Andrews, it was constructed from 1858-1881. Originally designed to hold 250 people, it became overcrowded in the 1950s with 2,400 patients. It was forcibly closed in 1994 due to changes in treatments of patients.