Madison is a city in and the county seat of Jefferson County, Indiana, United States, along the Ohio River. As of the 2010 United States Census its population was 11,967. Over 55,000 people live within 15 miles of downtown Madison. Madison is the largest city along the Ohio River between Louisville and Cincinnati. In 2006, the majority of Madison's downtown area was designated a National Historic Landmark—133 blocks of the downtown area is known as the Madison Historic Landmark District.