Guthrie is a city and county seat in Logan County, Oklahoma, United States, and a part of the Oklahoma City Metroplex. The population was 10,191 at the 2010 census, a 2.7 percent increase from the figure of 9,925 in the 2000 census. First known as a railroad station stop, after the Land Run of 1889, Guthrie immediately gained 10,000 new residents, who began to develop the town.