Calne is a town and civil parish in Wiltshire, southwestern England, at the northwestern extremity of the North Wessex Downs hill range, a designated Area of Outstanding Natural Beauty. Calne is on a small river, the Marden, that rises 2 miles away in the Wessex Downs, and is the only town on that river. It is on the A4 road national route 19 mi east of Bath, 6 mi east of Chippenham, 13 mi west of Marlborough and 16 mi southwest of Swindon.