Hereford is a city in and county seat of Deaf Smith County, Texas, United States. It is 48 miles southwest of Amarillo. Its population was 14,972 at the 2020 census. It is the only incorporated locality named "Hereford" in the country. The area is known for its semiarid climate, with heavy farming and ranching throughout the area sustained by irrigation from the Ogallala Aquifer and the saltier Santa Rosa Aquifer beneath it.