Izium or Izyum is a city on the Donets River in Kharkiv Oblast, eastern Ukraine that serves as the administrative center of Izium Raion and Izium urban hromada. It is about 120 kilometres southeast of the city of Kharkiv, the oblast's administrative center. Izium has a population of 44,979, making it the second-most populous city in Kharkiv Oblast behind Kharkiv proper.