Wayne County is a county located in the Ozark foothills in the U.S. state of Missouri. As of the 2020 census, the population was 10,974. The county seat is Greenville. The county was officially organized on December 11, 1818, and is named after General "Mad" Anthony Wayne, who served in the American Revolution. As of August 28, 2023, Wayne County is designated the UFO Capital of Missouri, along with the city of Piedmont.