San Francisco de Asis is a town within the municipality of the Atotonilco El Alto located in the southeastern part of the state of Jalisco in Mexico. It is named after the Italian Saint Francis of Assisi. At the time of the census of 2005, the town had a population of 5,167 inhabitants. Its most distinctive features are the Fine Sanctuary of Our Lady of Los Altos and the fact that new tequila factories are located there.