Spiro is a town in Le Flore County, Oklahoma, United States. It is part of the Fort Smith, Arkansas-Oklahoma Metropolitan Statistical Area. The population was 2,164 at the 2010 census, a 2.8 percent decline from the figure of 2,227 recorded in 2000. Developed as a railroad station in an agricultural area in the late 19th century, the small town is notable for its proximity to the Spiro Mounds.