Prescott is a city in Pierce County, Wisconsin at the confluence of the St. Croix River and Mississippi River. Prescott is located at the edge of the Minneapolis–St. Paul metropolitan area. The population was 4,333 at the 2020 census, making it the second-largest city in the county after River Falls, and the largest entirely within Pierce County. Prescott was home to the mother house of the Franciscan Servants of Jesus.