The Madonna Inn is a motel in San Luis Obispo, California. Opened for business in 1958, it quickly became a landmark on the Central Coast of California. The Inn was created by Alex Madonna, a successful construction magnate and entrepreneur (d. April 2004), and his wife Phyllis. The well-known motor inn, which includes a restaurant and bakery, is prominently located on the west side of US Route 101 and situated on the lower eastern portion of Cerro San Luis Obispo.