San Antonio Huista is a town and municipality in the Guatemalan department of Huehuetenango. It is located 362 kilometers from Guatemala City. The predominant language is Spanish, while approximately 20% of the population speak indigenous languages, the majority speaking Mam. The municipality of San Antonio Huista is situated at 1240 metres above sea level, with a population of 16,697. It covers an area of 60.4 km2.