Yzeures-sur-Creuse is a commune in the department of Indre-et-Loire, Centre-Val de Loire, France. It is one of the oldest towns in Touraine, occupation dating back to the Upper Paleolithic era earlier than 10,0 CE. Today, it's a village of 1300 inhabitants, situated in a rural setting. The town benefits from the spa activity of the nearby town of La Roche-Posay. Yzeures also offers a range of tourism activities and second homes are numerous. Its inhabitants are called Yzeurois, Yzeuroises.