Port Barre is a town in St. Landry Parish, Louisiana, United States. The town began in 1760 as an Indian trading post at the place where Bayou Teche flows out of Bayou Courtableau. The population was 2,055 at the 2010 census, down from 2,287 in 2000. It is part of the Opelousas–Eunice Micropolitan Statistical Area.