Spartanburg County is a county located on the northwestern border of the U.S. state of South Carolina. The 2016 population estimate is 301,463, making it the fifth-most populous county in South Carolina. Its county seat is Spartanburg. Spartanburg County is included in the Spartanburg, SC Metropolitan Statistical Area, which is also included in the Greenville–Spartanburg–Anderson, SC Combined Statistical Area. The USS Spartanburg County (LST-1192) is named after the county.