Sayre is a city in and the county seat of Beckham County, in western Oklahoma, United States. It is halfway between Oklahoma City and Amarillo, Texas on Interstate 40 and the former U.S. Route 66. The population was 4,809 at the time of the 2020 census, an increase over the 4,375 figure from the 2010 census, and the largest population ever recorded by a census since Sayre's founding.