Santa Cruz County, officially the County of Santa Cruz, is a county on the Pacific coast of the U.S. state of California. As of the 2020 census, the population was 270,861. The county seat is Santa Cruz. Santa Cruz County comprises the Santa Cruz–Watsonville, CA Metropolitan Statistical Area, which is also included in the San Jose–San Francisco–Oakland, CA Combined Statistical Area. The county is on the California Central Coast, south of the San Francisco Bay Area region.