Portopalo di Capo Passero is a comune in the Province of Syracuse, Sicily. The southernmost commune of the island of Sicily, it is about 220 kilometres southeast of Palermo and about 45 kilometres southwest of Syracuse. As of February 2017, it had a population of 3,916 and an area of 14.9 square kilometres. The nearest city is Pachino with a population of nearly 10,000. Portopalo belonged to the municipality of Pachino until 1975 when it became an autonomous municipality itself.