Henderson is an unincorporated community and former town in Mason County, West Virginia, United States, at the confluence of the Ohio and Kanawha Rivers. The population was 231 at the 2020 census. It is part of the Point Pleasant, WV–OH Micropolitan Statistical Area. The town was incorporated in 1893 and named for Samuel Bruce Henderson, who owned the townsite at the time. The town was unincorporated following a public hearing on August 11, 2022.