Whitesville is a home rule-class city in Daviess County, Kentucky, United States. The population was 580 as of the 2020 Census, up from 552 as of the 2010 census. It is included in the Owensboro, Kentucky Metropolitan Statistical Area. The city was founded in 1844 by Dr. William White, and named for him. The current mayor of Whitesville is Patsy Mayfield.