Manistique is the only city and county seat of Schoolcraft County in the U.S. state of Michigan. As of the 2020 census, the city population was 2,828. The city borders the adjacent Manistique Township, but the two are administered independently. The city lies on the north shore of Lake Michigan at the mouth of the Manistique River, which forms a natural harbor that has been improved with breakwaters, dredging, and the Manistique East Breakwater Light. The city is named after the river.