San Quirico d'Orcia is a comune of about 2,500 inhabitants in the Province of Siena in the Italian region Tuscany, located about 80 kilometres southeast of Florence and about 35 kilometres southeast of Siena inside the Valdorcia landscape. It is named in honor of Saint Quiricus. Located on the Via Francigena, San Quirico d'Orcia borders the municipalities of Castiglione d'Orcia, Montalcino and Pienza.