Santa Ana is a district in the City of Manila, Philippines. It is located on the city's southeast, bordering the cities of Mandaluyong and Makati in the east, the city districts of Paco and Pandacan in the west, and Santa Mesa in the north. It is part of the 6th congressional district of Manila, with thirty-five barangays. Based on the 2020 national census, the Philippine Statistics Authority reports that the district has a population of 203,598.