Otisville is a village in Orange County, New York, United States. The population was 969 at the 2020 census. It is part of the Poughkeepsie–Newburgh–Middletown, NY Metropolitan Statistical Area as well as the larger New York–Newark–Bridgeport, NY-NJ-CT-PA Combined Statistical Area. The village of Otisville is in the town of Mount Hope, located near the western town line. The mayor of Otisville is Brian Carey.