Prairie County is in the Central Arkansas region of the U.S. state of Arkansas. The county is named for the Grand Prairie, a subregion of the Arkansas Delta known for rice cultivation and aquaculture that runs through the county. Created as Arkansas's 54th county in 1846, Prairie County is home to four incorporated towns, including DeValls Bluff, the southern district county seat, and two incorporated cities, including Des Arc, the northern district county seat.