Otis is an unincorporated community in Lincoln County, Oregon, United States, a half mile north of Otis Junction on Oregon Route 18. It is near the Salmon River. Otis post office was established in 1900 and was named after Otis Thompson, nephew of Archibald S. Thompson, the postmaster. U.S. Route 101 used to pass through Otis until a curvy and hilly section of road was rerouted in the 1960s.