Little Missenden is a village and civil parish on the River Misbourne in Buckinghamshire, England. It is in the Chiltern Hills, about 3 miles southeast of Great Missenden and 3 miles west of Amersham. The village lies on the River Misbourne in the Misbourne valley. The parish includes the villages of Holmer Green, Hyde Heath and Little Kingshill, and the hamlets of Beamond End, Brays Green, Mop End and Spurlands End.