Hermann is a city in and the county seat of Gasconade County, Missouri, United States. It has been the county seat since 1842. It is near the center of the Missouri Rhineland and south of the Missouri River. The population was 2,185 at the 2020 census. Described as a Rhineland village, the city is the commercial center of the Hermann American Viticultural Area, whose seven wineries produce about one-third of the state's wine.