LaGrange County is a county located in the U.S. state of Indiana. As of 2020, the population was 40,446. The county seat is LaGrange, Indiana. The county is located in the Northern Indiana region known as Michiana and is about 55 miles east of South Bend, 105 miles west of Toledo, Ohio, and 175 miles northeast of Indianapolis. The area is well known for its large Amish population.