Miccosukee is a small unincorporated community and census-designated place in northeastern Leon County, Florida, United States. The population was 383 at the 2020 census. It is part of the Tallahassee, Florida Metropolitan Statistical Area. It is located at the junction of County Road 59 and County Road 151. Miccosukee was a major center of the Miccosukee tribe, one of the tribes of the developing Seminole nation, during the 18th century.