Ortona is an unincorporated area and a populated place in Glades County, Florida. One of the area's attractions is the Ortona Indian Mound Park, which preserves part of the Ortona Prehistoric Village, and the hiking trail through that area. The prehistoric mounds, canoe canals and earthworks were constructed by Native Americans across a five-square-mile region along the north side of the Caloosahatchee River. The site is located on SR 78, north of LaBelle.